What is Acyclovir – Troubleinthepeace

To help readers have an accurate view of the drug Acyclovir. webgiaidap.com would like to send you basic information about drugs such as: What is Acyclovir; uses; dosage; side effects; How to preserve, as well as measures to overdose drugs …. Let’s find out and refer!

What is acyclovir?

Acyclovir is a nucleic acid analogue synthesized from guanosine. This is an antiviral drug that reduces the production of viral DNA.

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Acyclovir is mainly used to treat conditions such as herpes simplex virus infections; chickenpox and shingles.

In addition, the drug has other applications in the prevention of cytomegalovirus infection after transplantation and in the prevention of serious complications of Epstein-Barr virus infection.

Aciclovir can be introduced into the body through inhalation, or by injection.

What are the forms of Acyclovir?

Aciclovir is available in several forms. Specifically as:

200 mg tablet form; 400mg; 800mg; Capsule 200mg Powder for injection 1g; 500mg; 250mg (as sodium salt) Oral suspension: 5g/125ml vial; 4g/50ml Type 3g, 15g ointment for external use 5%Tube 4.5g eye ointment 3%Type 2g, 10g cream for topical use 5%

The effects of acyclovir

Aciclovir is a nucleoside analogue (acycloguanosin), which is selectively active on cells infected with the herpes virus.

To be effective, acyclovir must be phosphorylated to the active form, acyclovir triphosphate.

In the first stage aciclovir is converted to aciclovir monophosphate by the viral enzyme thymidinekinase. It is then converted to aciclovir diphosphate and triphosphate by a number of other cellular enzymes.

Acyclovir triphosphate inhibits viral DNA synthesis and viral replication without affecting the normal metabolism of cells.

Acyclovir has good effects in the treatment of diseases such as:


Treats infections caused by certain viruses.Acyclovir is also used to treat sores around the mouth (caused by herpes simplex), shingles (caused by shingles), and chickenpox. treatment of genital herpes outbreaks. In patients with recurrent HSV, the drug acyclovir is used to help reduce the number of relapses. Antiviral potential. However, it does not cure the infection. It helps the sores to heal faster. Also keeps new sores from getting bigger, and relieves pain/itching. May help relieve pain after sores heal. People with weak immune systems. Acyclovir can reduce the risk of the virus spreading to other parts of the body and causing serious infections.

Who can use Acyclovir?

Acyclovir comes in many forms, each with different indications:

Tablet form

Indicated for people infected with herpes simplex skin and mucous membranes. Includes: Genital herpes onset; Herpes relapses. In addition, Acyclovir tablets also prevent re-infection with herpes simplex in immunocompetent people, people with shingles.

Acyclovir cream

Indications for patients infected with herpes simplex virus include: Herpes labia in initial and recurrent form; Genital herpes including both onset and recurrence

Ointment for the eyes

This form of medicine is indicated for patients with keratitis caused by herpes simplex.

Dosage of Acyclovir

You should know, any drug, the dose and duration of use also depends on:

Health status User age

Acyclovir is no exception.

Dosage of the drug for adults?

For each disease, Acyclovir will be used in different doses. Specifically:

People infected with Herpes Simplex – mucosa/immune system

Oral: Initial phase or intermittent treatment: 200 mg daily is recommended. Use up to 5 times a day, each time 4 hours apart. Recurrent disease stage: 200 mg/time should be taken. 4 hours apart each time. Should be taken 5 times/day. If used for 5 days should take 400 mg / time. Drink 3 times a day.

People infected with orolabial HSV

Oral: 400 mg should be taken. Drink 5 times a day, should drink within 5 days.

Intravenous form: Initial severe phase: 5-10 mg/kg body weight. May be administered directly into a vein once a day. Should be injected from 5-7 days.

Patients infected with Orolabial HSV for patients with HIV

Patients take 400 mg / 3 times / day. Use from 7-14 days.

People with Herpes Simplex encephalitis

Intravenous injection at the rate of 10-15 mg/kg body weight. It is recommended to use the drug for 10 to 21 days.

Dosage for people with Herpes Simplex – prevent

Patients with normal immune system: 400 mg orally twice a day; 200 mg dose can be substituted 3 to 5 times a day.

People with HIV: orally 200 mg / 3 times / day or 400 mg / 2 times / day.

Subjects infected with HIV, vaginal herpes: 400-800 mg orally. Divide into 2 to 3 times/day.

Subjects with shingles

Acute phase: Take 800 mg / 5 times / day, each time 4 hours apart. Use the drug for 7-10 days.

Severely immunocompromised persons: Infusion 10 mg/kg body weight intravenously. Use the drug from 7-14 days.

Shingles chickenpox: Take 800 mg / 4 times / day. Use for 5 days (applicable to patients with normal immune system).

For immunocompromised people

Infusion of 10 mg/kg body weight intravenously. Use for 7 to 10 days or until no new lesions for 48 hours;

After the fever was gone, there were no signs of organ-related diseases. Patients can switch to bed 800 mg/4 times/day.

Dosage for children

According to experts, children can use the drug acyclovir. Dosage for children is as follows:

Children with Herpes Simplex

In case of HSV infection in infants: Under 3 months old: 10-20 mg/kg or 500 mg/m2 intravenously. The drug can be used for 10 to 21 days.

Children with Herpes Simplex – mucosal/host immunity

Children from 3 months to 11 years old: In the initial stage, take 10-20 mg/kg. Drink 4 times a day. Or take from 8 to 16 mg/kg. Use 5 times a day, use from 7-10 days.

Children 12 years and older, over 40 kg: Initial phase, severe phase, and relapse phase: use the same dose as the adult dose.

Usual Pediatric Dose for Herpes Simplex – mucosal/immunocompromised

Need to treat HSV skin and mucosal infections: Oral medication: Take 1 g/day, divided into 3-5 doses per day. Use from 7-14 days.

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Children 3 months to 11 years of age need to be administered directly into a vein. Dosage ranges from 5-10 mg/kg or 250-500 mg/m2. The drug should be maintained for 7 to 14 days.

Children 12 years of age and older and over 40 kg also use the same dose as adults, in the form of intravenous infusion.

Children with Herpes Simplex encephalitis

For children from 3 months to 11 years old: 10-20 mg/kg or 500 mg/m2 intravenously. This dose is maintained for 10 to 21 days.

In case of children from 12 years of age and older: the same dose as adults will be applied.

Children with Herpes Simplex – prevent

Oral: Children under 12 years old: 80 mg/kg/day. It should be divided into 3-4 times a day. Absolutely do not use more than 1g/day.

Children 12 years and older: apply adult dosage

Intravenous infusion form: In the critical phase, use 5 mg/kg, or 250 mg/m2 for intravenous infusion.

Usual Pediatric Dose for Shingles

For children 12 years and older, with a normal immune system. It is recommended to take 800 mg/5 times/day. Take each dose 4 hours apart. Can be used for 5 to 10 days.

If the subject is infected with HIV, parents give the child a dose of 20 mg/kg/ 4 times/day. Maximum daily use is 800mg. It is recommended to use 7-10 days for the drug to take effect

How should acyclovir be used for maximum effectiveness?

In order for the drug to maximize its effectiveness, as well as ensure safety for users, you should:

Use the drug in the correct dose as prescribed by the doctorWhen taking the drug with or without food Should take the drug 2-5 times a day or as directed by the doctor and pharmacist Should drink a lot of water when using the drug If Taking medicine in liquid form should shake the bottle well before use. With medicine in water form, you should measure the dose using a measuring device or use a special spoon Absolutely do not use a spoon to take food to Measure the amount of medicine The drug works best when you have the first signs of the disease Do not delay treatment to reduce the effect of the drug Should use the right dose, at the right time as prescribed by the doctor Do not change the dose dose as well as stop using the drug without a doctor’s instructions. Inform the doctor or go to the nearest medical facility when you have unusual symptoms.

Who is Acyclovir contraindicated for?

The following people should not use Acyclovir:

Patients with hypersensitivity to the components of the drug Aciclovir For Aciclovir cream, patients who are too allergic to propyleneglycol should absolutely not use the drug.

Does acyclovir have any side effects?

The answer is yes. When using acyclovir, patients often experience some unwanted side effects as follows:

Rash on the whole body Effects on the digestive system such as causing nausea; vomiting; diarrhea; Abdominal pain Patient may lose hair May cause liver enzymes to increase Hematological indicators in the body are reduced Dizziness, dizziness, headache, body fatigue There is a burning and stinging sensation when applying the medicine Irritation and inflammation in place

What precautions should patients take when using Acyclovir?

To avoid unwanted side effects caused by the drug. Before using the drug you need:

Inform your doctor about your health status as well as the names of the drugs you are using. During the course of taking the medicine, you should use it as directed by your doctor or according to the instructions on the package. When using the drug, if you find yourself with any abnormal signs. You should immediately contact your doctor.

What drugs does acyclovir interact with?

Same with other drugs. Acyclovir will also interact with some other medications. This interaction will change the effectiveness of the drug. Besides, it can also cause unwanted side effects, affecting the health of the patient.

Therefore, when a doctor prescribes a drug with Acyclovir. You need to

Tell your doctor about all medications, vitamins, and herbal supplements you are taking. Based on that, your doctor can help you prevent or control drug interactions.

Currently Acyclovir may interact with the following drugs and products:

Interferon KetoconazoleProbenecidZidovudine

How is acyclovir stored?

With each type of acyclovir, there will be different ways of preserving:

Tablets: Store below 25°C and need to be kept dry Cream: Store below 25°C Ophthalmic ointment: Store below 25°C Acyclovir cream contains a specially formulated alkali and should not be diluted .

Can acyclovir be used for herpes simplex virus infection and chickenpox?

The answer is yes. Because the use of Acyclovir is to treat patients infected with herpes simplex virus; and chickenpox.

Note that a doctor’s consultation is required. Absolutely do not arbitrarily use drugs.

Can a person driving a car take Aciclovir?

One of the side effects that acyclovir causes is low blood pressure, headache, dizziness, drowsiness, and nausea.

Therefore, while driving or operating machinery. You absolutely must not use drugs.

Is acyclovir addictive?

According to experts, whether you abuse drugs or use drugs for a long time. Absolutely will not cause addiction or create habits for patients.

What to do when you forget a dose?

If you miss a dose of acyclovir, you need to take it as soon as you realize it.

In case it is almost time to take the next dose.

Skip the missed dose and continue with your dosing schedule.

Never take an extra dose to make up for the missed dose.

If you often miss a dose, ask a loved one to remind you. Or Please consult your doctor to discuss changing your dosing schedule.

What if Acyclovir overdose?

Medicines are only effective when used at the right dose and for the right duration. Therefore, you should never overdose.

If you overdose, you need to immediately contact a specialist or go to the nearest specialized medical facility.

Note: When traveling should bring the box, cover or label of the medicine to help the doctor with the necessary information. From there, timely and effective remedial measures will be taken.

Absolutely do not give your medicine to others to use without understanding the condition; opponent’s health.

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Above is some information about acyclovir provided by webgiaidap.com. All the above information is for reference only, you should not do it yourself. Should follow the instructions of the specialist.


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