Test GPT and GOT is one of the biochemical methods used to evaluate liver function. But, are elevated GPT and GOT tests simply a sign of liver disease or are they related to other diseases?
About GPT and GOT
In a nutshell, GOT and GPT are two enzymes responsible for amine exchange (also known as transaminase), which are found in many different organs of the body. Among the metabolic enzymes, GOT and GPT have much higher activity intensity and are widely used in clinical practice. GOT occurs mainly in cardiac muscle cells, while GPT is abundant in cells such as liver tissue. Therefore, an increase in these enzymes will reflect liver cell damage.
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In addition to GOT and GPT indicators, AST (full name is Aspartate aminotransferase) or SGOT (full name is Serum Glutamic Oxaloacetic Transaminase) are two substances present in the cytoplasm and mitochondria of cells. AST is abundant in cardiac and skeletal muscle and is more abundant in the liver. AST is also detected in the kidneys, brain, pancreas, lungs, white blood cells, and red blood cells. In a normal person, there is AST 1000U/l). But the level of GPT will increase faster than GOT, increasing early before the appearance of jaundice or in the first week of jaundice (a persistent increase in advanced chronic hepatitis). If GOT activity, GPT increased more than 10 times, it means that liver parenchyma cells are now strongly destroyed. Lesser increases may occur with other forms of liver damage. GOT and GPT increase the highest in the first 2 weeks, then gradually decrease 7-8 weeks later.
Hepatitis due to poisoning
When the liver is poisoned, GOT and GPT both increase, but mainly GPT increases, possibly 100 times higher than normal. Especially when suffering from acute alcohol intoxication with delirium, being poisoned with carbon tetrachloride (CCl4), being infected with morphine or being poisoned with toxic chemicals… the GPT level spikes. The GOT/GPT ratio is > 1, with GOT being about 7 to 8 times higher than normal, or seen in people with liver disease and alcoholic hepatitis.
Chronic hepatitis, cirrhosis caused by alcohol and other causes
In chronic hepatitis, alcoholic cirrhosis or other causes, GOT will increase 2 to 5 times, GPT will increase less, GOT will increase more than GPT.
Due to acute biliary obstruction
If acute biliary obstruction and gallstones cause damage to the liver, the GOT and GOP levels in the liver will increase, possibly up to 10 times. But if the stone does not cause damage to the liver, this index will not increase.
With obstructive jaundice, the GOT and GPT index will increase slightly, insignificantly, combined with alkaline phosphatase will increase more than 3 times compared to the normal level. The GOT and GPT index increases slowly to very high levels (maybe more than 2000 U/l), then it drops suddenly within 12 – 72 hours, which is considered as one of the bile duct obstruction. acute.
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GOT is also increased in acute myocardial infarction, muscle diseases
The GOT index will be increased in acute myocardial infarction and muscle related diseases. At this time, GPT will be at normal level but GOT will increase very high. May go up to 1000 U/l, then gradually decrease to 50% within 3 days. It will also drop below 100 U/l within 1 week when liver shock is diagnosed with parenchymal cell necrosis such as cirrhosis, arrhythmia, sepsis.
Besides the above cases, GOT and GPT also increased slightly in some cases with indications for treatment such as taking anticoagulants, taking oral contraceptives, etc.
Thus, with the above information, hopefully the question “Is increased GPT and GOT simply liver disease?” of readers has been answered specifically. To be sure, ask for advice from a specialist for the best treatment or self-care regimen.
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