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Abstain from alcohol. Do not use with morphine antagonists. Use with caution with CNS depressants, other derivatives of morphine.
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Mild & transient: constipation, nausea, vomiting, dizziness, somnolence, bronchospasm, skin irritation, respiratory depression. Sleepy. Risk of drug overdose when drug overdose, withdrawal syndrome when stopping the drug suddenly.
After oral administration, the elimination half-life is 2-4 hours, the cough suppressant effect appears within 1-2 hours and may persist for 4-6 hours. Codeine is metabolised in the liver and eliminated by the kidneys as either free or conjugated with glucuronic acid. Codeine or its metabolites are excreted in the feces very little. Codeine crosses the placenta and small amounts cross the blood-brain barrier.
Codeine is a methylmorphine that replaces the position of hydrogen in the hydroxyl group associated with the aromatic nucleus in the morphine molecule, so codeine has analgesic and cough-reducing effects. However, codeine is better absorbed after oral administration, causing less constipation and less bile spasm than morphine. At therapeutic doses, it causes less bile constriction than morphine) and is less addictive than morphine.Codeine is effective in reducing pain in mild to moderate pain (the analgesic effect of codeine can be attributed to a conversion of about 10% of the dose administered to morphine). Because it causes a lot of constipation if used for a long time, it is recommended to use codeine in combination with anti-inflammatory drugs, non-steroidal anti-inflammatory drugs to increase pain relief and relieve constipation. Coughing center in the medulla oblongata, codeine dries up respiratory secretions and increases the viscosity of bronchial secretions. Codeine is not effective enough to relieve severe cough. Codeine is a cough suppressant in case of dry cough causing insomnia. Codein causes a decrease in intestinal motility, so it is a very good drug in the treatment of diarrhea caused by diabetic neuropathy. Not indicated for acute diarrhea and diarrhea due to infection.
Dry cough.Mild to moderate pain.
Dosage – how to use:
Mild to moderate pain:Oral: 30 mg every 4 hours if needed: the usual dose ranges from 15 to 60 mg, up to a maximum of 240 mg/day. Children 1 – 12 years old: 3 mg/kg/day, divided into small doses (6 doses). Intramuscular: 30 – 60 mg each time 4 hours apart if necessary. Dry cough: 10 – 20 mg 1 time, 3 – 4 times a day (using liquid form of 15 mg/5 ml), not to exceed 120 mg/day. Children 1 – 5 years old use 3 mg each time, 3 – 4 times / day (5 mg/5ml liquid), not to exceed 12 mg / day, 5 – 12 years old use 5 – 10 mg each time, divided 3-4 times a day, not to exceed 60 mg/day.
Hypersensitivity to codeine or other components of the drug. Children under 1 year old. Liver disease, respiratory failure.
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Common: headache, dizziness, thirst and strange sensations, nausea, vomiting, constipation, urinary retention, little urination, tachycardia, bradycardia, palpitations, weakness, orthostatic hypotension.Uncommon: allergic reactions such as pruritus, urticaria, respiratory depression, euphoria, euphoria, restlessness, stomach pain, bile duct spasm. Rare: anaphylaxis, hallucinations, disorientation, visual disturbances, convulsions, circulatory failure, flushing, sweating, fatigue. Addiction: Using codeine for a long time with a dose of 240-540 mg/day can cause addiction. Common symptoms include lack of medication and restlessness, tremors, muscle twitching, sweating, and runny nose. May cause psychological, physical and drug dependence.
Terpin hydrate liquefies secretions by direct stimulation of secretory cells, thereby increasing secretion of bronchial secretions which facilitate the elimination of secretions (sputum) by the cough reflex.
– Can be used in combination with some other preparations. For example: Codeine in the treatment of cough caused by bronchitis.
– Use in combination with Codeine, codeine terpine tablets to make cough medicine, expectorant, treat ulcers, mucous membranes of the respiratory tract.
– Often combined with Codeine, Sodium benzoate has the effect of treating cough, expectorant in the treatment of acute or chronic bronchitis.
Adult dosage: Terpin hydrate is commonly used as a compounded drug. Dosage can vary from 85-130 mg taken 3-4 times per day.Pediatric dosage: Dosage for children has not been studied and determined. Consult your doctor if you are giving this medicine to a child.
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You may experience drowsiness, dizziness, loss of appetite, nausea, or upset stomach. If any of these side effects persist or cause discomfort, tell your doctor. Also, to avoid feeling dizzy when getting up from a lying or sitting position, get up slowly. Tell your doctor if you experience slow pulse, mental confusion, mood swings, skin rash, breathing problems. If you notice other side effects not listed here, contact your doctor or pharmacist. Not everyone experiences these side effects. There may be other side effects not mentioned. If you have any questions about side effects, consult your doctor or pharmacist.